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benefits of green tea
Cell signaling pathways in the neuroprotective actions of the green tea polyphenol (-)-epigallocatechin-3-gallate: implications for neurodegenerative diseases
Source: J Neurochem. 2004 Mar;88(6):1555-69
     This is a review paper. Both experimental and epidemiological evidence demonstrate that flavonoid polyphenols, particularly from green tea and blueberries, improve age-related cognitive decline and are neuroprotective in models of Parkinson's, Alzheimer's diseases and cerebral ischemia/reperfusion injuries. The article, in reference to 152 research publications, reviews the currently (Mar, 2004) established mechanisms involved in the beneficial health action and emerging studies concerning the putative novel molecular neuroprotective activity of green tea and its major polyphenol (-)-epigallocatechin-3-gallate (EGCG).
Two stages of cancer prevention with green tea
Source: J Cancer Res Clin Oncol 1999 Nov;125(11):589-97
     This is a research review paper on benefitial effects of green tea. (1) introduced the present status (1999) of clinical trials cancer prevention with green tea supported by the Chemoprevention Branch of the National Cancer Institute in the United States. (2) evidences of cancer prevention with green tea at gene level and cohort studies with over 8000 individuals. (3)for cancer treatment: to delay cancer onset, (green tea diet) at least 10 cups of green tea per day, for recurrence rate of stages I and II breast cancer patients, consumming 5 cups of green tea per day is lower than those taking less than 4 cups per day. (4)two-stage approach to analyzing cancer prevention with green tea is proposed
Green tea consumption and the risk of pancreatic and colorectal cancers
Source: Int J Cancer. 1997 Jan 27;70(3):255-8
     Benefits of gren tea in cancer prevention was examined via a large population-based case-control study, with cases of 931 colon cancer, 884 rectum cancer, 451 pancreas cancer, and 1552 controls in Shanghai, China. An inverse association with each cancer was observed with increasing amount of green tea consumption, with the strongest trends for rectal and pancreatic cancers. For men, compared with non-regular tea drinkers, odds among those in the highest tea consumption category (green tea diet, > or = 300 g/month) were 0.82 for colon cancer, 0.72 for rectal cancer and 0.63 for pancreatic cancer. For women, the respective odds for the highest consumption category (green tea diet > or = 200 g/month) were 0.67, 0.57 and 0.53. The findings provide further evidence that green tea drinking may lower the risk of colorectal and pancreatic cancers
Reduced risk of esophageal cancer associated with green tea consumption
Source: J Natl Cancer Inst. 1994 Jun 1;86(11):855-8
     A case-control study of 902 patients and 1552 control subjects found: statistically significant decreases in risk of esophageal cancer among tea drinkers were observed for both men (odds ratio = 0.43) and women (odds ratio = 0.40).
Green tea constituent (-)-epigallocatechin-3-gallate inhibits Hep G2 cell proliferation and induces apoptosis through p53-dependent and Fas-mediated pathways
Source: J Biomed Sci. 2003 Mar-Apr;10(2):219-27
     Experiments of effects of green tea component EGCG on human liver cancer cell line Hep G2 found: EGCG inhibited the proliferation of Hep G2. Suggest a mechanism for benefit of green tea in liver cancer prevention.
A case-control study on drinking green tea and decreasing risk of cancers in the alimentary canal among cigarette smokers and alcohol drinkers
Source: Zhonghua Liu Xing Bing Xue Za Zhi (Chinese Journal of Epidemiology). 2003 Mar;24(3):192-5
     A population based case-control study on benefit of green tea in prevention of gastric cancer, liver cancer, esophageal cancer among alcohol drinkers or cigarette smoker. Cancer cases: stomach - 206, liver - 204, esophageal - 218. Found: among alcohol drinkers, green tea drinking decreased risk of cancers: stomach - 81%, liver - 78%, esophageal - 39%; among cigarette smokers: stomach - 16%, liver - 43%, esophageal - 31%.(Article in Chinese)
A population-based case-control study of lung cancer and green tea consumption among women living in Shanghai, China
Source: Epidemiology. 2001 Nov;12(6):695-700
     Epidemiologic study of 1324 women lung cancer patients (649) and contral group (675) found benefits of green tea consumption: Among nonsmoking women, consumption of green tea was associated with a reduced risk of lung cancer (OR = 0.65; 95% CI = 0.45-0.93), and the risks decreased with increasing consumption.
Molecular targets for green tea in prostate cancer prevention
Source: J Nutr. 2003 Jul;133(7 Suppl):2417S-2424S
     The study of green tea's benefits suggest that there are multiple targets for prostate cancer chemoprevention by green tea and highlight the need for further studies to identify novel pathways that may be modulated by green tea or its polyphenolic constituents that could be further exploited for prevention and/or treatment of prostate cancer.
Epigallocatechin-3-gallate is a potent natural inhibitor of fatty acid synthase in intact cells and selectively induces apoptosis in prostate cancer cells
Source: Int J Cancer. 2003 Oct 10;106(6):856-62
     Green tea component EGCG was shown to act as a natural inhibitor of fatty acid synthase (FAS), and to selectively cause apoptosis in prostate cancer cells but not in nontumoral fibroblasts. The findings establish EGCG as a potent natural inhibitor of FAS in intact cells and strengthen the molecular basis for the use of EGCG as a chemopreventive and therapeutic antineoplastic agent
Tea polyphenol (-)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines
Source: Cancer Res. 2003 Nov 15; 63(22): 7563-70
     Green tea prevents cancer by inhibiting DNA methyltransferase and reactivating methylation-silenced genes. The benefitial effects of green tea were demonstrated with cell lines of colon cancer, esophageal cancer and prostate cancer
Protective effect of green tea against prostate cancer: a case-control study in southeast China
Source: Int J Cancer. 2004 Jan 1;108(1):130-5
     A case-control study on protective effect of green tea against prostate cancer was carried out. Total of 404 patients were studied, among them, 130 cases of prostate cancer and 274 hospital inpatients without prostate cancer as contral group. Significant benefit of green tea against prostate cancer was found. The longer, and the more one drinks green tea, the less risk of getting prostate cancer. The odds ratio was 0.27 for those (green tea diet) drinking more than 3 cups (1 litre) of green tea daily compaired to non-tea drinkers, suggesting that green tea is protective against prostate cancer.
Radiation induced-tubulogenesis in endothelial cells is antagonized by the antiangiogenic properties of green tea polyphenol (-) epigallocatechin-3-gallate.
Source: Cancer Biol Ther. 2003 Nov-Dec; 2(6): 642-9
     The study of green tea benefits shown: Pretreatment of the cells with green tea extract epigallocatechin-3-gallate (EGCg), a green tea catechin that possesses anti-angiogenic properties, prevented most of the ionizing radiation (IR)-induced cellular and molecular events.

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