benefits of green tea:cancer prevention:green tea and prostate cancer prevention


Molecular targets for green tea in prostate cancer prevention
Source: J Nutr. 2003 Jul;133(7 Suppl):2417S-2424S
     The study of green tea's benefits suggest that there are multiple targets for prostate cancer chemoprevention by green tea and highlight the need for further studies to identify novel pathways that may be modulated by green tea or its polyphenolic constituents that could be further exploited for prevention and/or treatment of prostate cancer.
Epigallocatechin-3-gallate is a potent natural inhibitor of fatty acid synthase in intact cells and selectively induces apoptosis in prostate cancer cells
Source: Int J Cancer. 2003 Oct 10;106(6):856-62
     Green tea component EGCG was shown to act as a natural inhibitor of fatty acid synthase (FAS), and to selectively cause apoptosis in prostate cancer cells but not in nontumoral fibroblasts. The findings establish EGCG as a potent natural inhibitor of FAS in intact cells and strengthen the molecular basis for the use of EGCG as a chemopreventive and therapeutic antineoplastic agent
Tea polyphenol (-)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines
Source: Cancer Res. 2003 Nov 15; 63(22): 7563-70
     Green tea prevents cancer by inhibiting DNA methyltransferase and reactivating methylation-silenced genes. The benefitial effects of green tea were demonstrated with cell lines of colon cancer, esophageal cancer and prostate cancer
Protective effect of green tea against prostate cancer: a case-control study in southeast China
Source: Int J Cancer. 2004 Jan 1;108(1):130-5
     A case-control study on protective effect of green tea against prostate cancer was carried out. Total of 404 patients were studied, among them, 130 cases of prostate cancer and 274 hospital inpatients without prostate cancer as contral group. Significant benefit of green tea against prostate cancer was found. The longer, and the more one drinks green tea, the less risk of getting prostate cancer. The odds ratio was 0.27 for those (green tea diet) drinking more than 3 cups (1 litre) of green tea daily compaired to non-tea drinkers, suggesting that green tea is protective against prostate cancer.





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