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Cell signaling pathways in the neuroprotective actions of the green tea polyphenol (-)-epigallocatechin-3-gallate: implications for neurodegenerative diseases
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| Source: J Neurochem. 2004 Mar;88(6):1555-69 |
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This is a review paper. Both experimental and epidemiological evidence demonstrate that flavonoid polyphenols, particularly from green tea and blueberries, improve age-related cognitive decline and are neuroprotective in models of Parkinson's, Alzheimer's diseases and cerebral ischemia/reperfusion injuries. The article, in reference to 152 research publications, reviews the currently (Mar, 2004) established mechanisms involved in the beneficial health action and emerging studies concerning the putative novel molecular neuroprotective activity of green tea and its major polyphenol (-)-epigallocatechin-3-gallate (EGCG). |
